In the last decades, several types of all-ceramic systems and restorative approaches have been developed in order to satisfy the patients’ increasing esthetic demand. Today the challenge was to develop an all-ceramic approach characterized by excellent esthetic and function outcomes with minimal thickness in order to preserve as much as possible tooth structure and therefore the reliability of the prosthetic outcome. In this sense, adhesion coupled with monolithic ceramic restorations and minimal-invasive approaches are the key points to improve the mechanical properties of the restorations, and tooth-like esthetic and functional features. These modern restorative approaches, in many clinical situations, allow to achieve excellent esthetic outcomes saving tooth structure and preserving the soft tissues. The lecture is aiming to describe the potential of the All-Ceramic monolithic reconstruction in the daily practice in the anterior and posterior both in case of teeth and implant supported rehabilitations.