Novel adhesive techniques and bonded restorations are able to provide patients, clinicians, and dental technicians with treatment alternatives that until recently would require invasive approaches and sacrifice of pristine dental structure. Through microscopically interaction between biomaterials and dental structure, highly-esthetic and long-lasting clinical solutions can be attained while simultaneously preserving the integrity of the enamel and dentin. The adhesive revolution has overturned established dogmas and concepts by advancing our profession with groundbreaking ultra-conservative philosophies that supported by the sealing and reinforcement of dental tissues. However, as newer adhesive dental materials and technologies are introduced at a very fast pace, it is essential that clinicians and dental technicians become familiar with their indications and limitations to provide the best restorative strategy for each individual patient. This presentation provides a systematic and scientific approach for selecting esthetic treatment modalities using adhesive techniques and CAD/CAM materials based on original research data with special emphasis on minimally-invasive adhesive techniques for materials design and selection.